Cyclic antidepressants also affect other chemical messengers, which can lead to a number of side effects.
Maprotiline, a tetracyclic antidepressant, also is FDA approved for depression.
A recent case-control study of 5,579 subjects age 67 to 84 found that the current use of lithium was higher (rate ratio = 2.08) among subjects who had been involved in an injurious motor vehicle crash compared with control subjects (Etminan et al., 2004) . H., Yale University School of Medicine to Kathy Lococo, 7/20/2005.
No information about drug interactions with lithium was reported in this study.
When there is a risk of the patient taking an overdose it is usually preferable to choose an SSRI, if a tricyclic is essential then lofepramine may be the safest drug.
Tricyclic antidepressants (with the exception of lofepramine) are more dangerous in overdose than other equally effective drugs recommended for routine use in primary care (1).
Examples of nonsedating antidepressants include the monoamine oxidase inhibitor moclobemide, the selective serotonin reuptake inhibitors fluoxetine, paroxetine, and nefazodone, and the serotonin and norepinephrine uptake inhibitor (SNRI) venlafaxine.
The effect of antidepressants on driving behavior was assessed with the standard deviation of lateral position (SDLP) test.
In certain cases, they relieve depression when other treatments have failed.
Cyclic antidepressants ease depression by impacting chemical messengers (neurotransmitters) used to communicate between brain cells.
Like most antidepressants, cyclic antidepressants work by ultimately effecting changes in brain chemistry and communication in brain nerve cell circuitry known to regulate mood, to help relieve depression.